Dual-effect hybrid facial filler/injectable containing two active ingredients, Calcium Hydroxyapatite (CaHA) and Hyaluronic Acid (HA), to lift and improve skin architecture.

Dual Effect Hybrid Facial Fillers South Africa

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Loss of volume and poor soft-tissue structural support are common forms of facial ageing. Most single-agent approaches, such as Hyaluronic Acid (HA) or bio-stimulator injections, are unable to individually provide the combined benefits of a HA lift and lasting collagen stimulation from Calcium Hydroxyapatite (CaHA).

Wrinkles and loss of volume in the face are a natural part of the ageing process. Therefore, we are fortunate that scientists have developed a range of products to help fight and effectively delay signs of ageing.


The new dual-effect Hybrid Injectable Facial Filler contains two active ingredients, Calcium Hydroxyapatite (CaHA) and Hyaluronic Acid (HA). It is aimed at improving the skin architecture by providing an immediate lift effect from hyaluronic acid and a sustained lifting effect from new collagen production that happens with calcium hydroxyapatite.

Find out more about our approach to hybrid fillers, or book a consultation with Dr Nerina Wilkinson + Associates.

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Frequently asked questions about Hybrid Facial Fillers

Our approach to hybrid facial filler treatments

At Dr Nerina Wilkinson + Associates we understand the importance of embracing the facial structures and skin as a whole. The goal is to achieve harmonious results using facial reshaping injectables and state-of-the-art skin rejuvenating treatments.

No area of the face exists in isolation, all are connected and often corrected indirectly through facial reshaping. Treating areas in isolation leads to exaggerated and aesthetically unattractive features.

Hybrid fillers are not just about restoring volume, it is also about the enhancement of skin quality for more holistic facial rejuvenation.

By understanding how all areas of the face are interconnected and how treating one area communicates with another facial area, we are able to use much less product and produce constant and beautifully, natural results.

Start your hybrid facial filler journey! Contact us to book a consultation.

How do Hyaluronic Acid (HA) and Calcium Hydroxyapatite (CaHA) work?

The Hyaluronic Acid particles work deep within the skin, where they help plump it up for an immediate lift effect, moreover, Calcium Hydroxyapatite particles support the body’s own collagen production, so new collagen fibres start to grow. As the gel slowly disappears over time, a firm and dense collagen network is built in its place for a gradual, long-lasting lift from Calcium Hydroxyapatite.

Who is the ideal candidate for hybrid facial filler procedures?

Once the Doctor has determined and confirmed your areas of concern by means of a detailed consultation, they will proceed. Hybrid facial fillers may be suitable for anyone with signs of ageing, who could benefit from potential improvements in skin architecture and facial soft tissue augmentation. It is ideal for the treatment of sagging skin on the lower face and for improving skin quality.

How are hybrid filler procedures performed?

The procedure is minimally invasive and performed through a series of injections using an ultra-thin needle. The new Dual Effect Hybrid Facial Filler contains 0.3% lidocaine hydrochloride, an anaesthetic, to reduce pain during treatment, making it as comfortable as other filler treatments.

What is the duration of a hybrid filler procedure?

Treatment time can vary between 30-45 minutes, depending on the area(s) treated. You will be able to go home right away, and no downtime is required. A 15-minute follow-up appointment is required 8 – 12 weeks after your treatment.

What are the benefits of hybrid facial fillers?

The new Dual Effect Hybrid Facial Filler may give you an immediate lift while stimulating your body’s own collagen production. Research shows that this hybrid filler offers a lifting effect as early as the second week after injection, and results have been demonstrated in 86% of 85 treated areas. In fact, 92% of patients treated with this hybrid filler reported an improvement in the general appearance of the facial areas that were treated.

The new Dual Effect Hybrid Facial Filler has an instant lifting effect, with results that improve for up to 3 months and can last for 1-3 years.

What areas can be treated with hybrid facial fillers?

Hybrid facial fillers can be used under the skin, in certain areas of the face, and cannot be injected around the eyes, the lips, or around the mouth. it is ideal for the treatment of lower face sagginess, accordion lines in the cheeks, jawline sculpting, skin tightening, and quality improvement in the lower face.


Not used in the midface, although its lifting effect can improve the midface Lateral face 

Lower face 


Glabellar or periocular areas Lips and perioral areas

What results can I expect with hybrid facial fillers?

Hybrid facial fillers may give you an immediate lift while stimulating your body’s own collagen production. Research shows that hybrid facial fillers offer a lifting effect as early as the second week after injection, and results have been demonstrated in 86% of 85 treated areas. In fact, 92% of patients treated with hybrid fillers reported an improvement in the general appearance of the facial areas that were treated.

How long do results from hybrid facial fillers last?

Hybrid facial fillers have an instant lifting effect, with results that improve for up to 3 months and can last for 1-3 years.

What do hybrid facial fillers cost?

The cost of treatment depends on your face shape, concerns, personal goals, how much product is required, and the treatment(s) required. You will be provided with an estimate after your initial consultation with one of our Aesthetic Doctors.

We are unable to provide you with an exact cost/quotation for pre-treatment as an in-depth consultation is part of our individualised and holistic Aesthetic Couture journey to help you achieve the results you desire; we quote on the steps required to achieve this outcome, not simply on the amount of product required.

Please contact us for any more information.

How long is the recovery period for hybrid facial fillers?

After the procedure, you will be able to go home right away and no downtime is required. You may have some swelling and bruising, but you should be able to return to normal activities within a few hours. You will need to follow your aftercare instructions carefully in order to ensure optimal results and recovery.

How many treatments do you need to complete a full hybrid facial filler treatment?

Depending on your areas of concern you can be expected to have between 2 – 3 sessions spaced at 6 – 8 week or 3-month intervals, depending on advice from your Doctor.

This will be discussed and determined during your consultation or after your first session.

Are hybrid facial fillers safe?

Hybrid filler procedures are normally safe when performed by a qualified Aesthetic Doctor.

Hyaluronic Acid-based Fillers are substances that have been used for a long time to improve features and surrounding skin. In the past, harmful substances used in filler procedures could cause adverse reactions and side effects.

As a result, doctors have continuously improved on and sought out better ingredients to help them perform this procedure safely, with minimal or no adverse reactions.

Dual Effect Hybrid Facial Fillers: Before and After

The initial consultation with an Aesthetic Doctor is very important. We will need your complete medical history so check your own records ahead of time and be ready to provide this information. After your initial consultation, your doctor will decide if the Hybrid Fillers are suitable for you.

You will have a comprehensive examination that includes a VISIA Skin Analysis and Next Motion photographs which track your before and after progress. Based on the results your doctor will be able to determine the best course of treatment.

It’s important to discuss your expectations frankly with your Aesthetic Doctor and to listen to her opinion. They will discuss the variables that may affect the procedure: such as your age, medical illnesses and social habits, as well as describe the procedure in detail, explaining its risks and limitations.

Don’t hesitate to ask any questions you may have, especially those regarding your expectations and concerns about the results.

What to do before Hybrid Facial Filler procedure


2 Weeks prior to your treatment, we advise you strongly to avoid:

  • Alcohol
  • Garlic
  • Lidocaine
  • Fish oil supplements
  • Aspirin or any other anti-inflammatory drugs for pain, swelling and/or fever, such as medicine containing diclofenac, mefenamic acid, indomethacin, or ibuprofen

Ask your doctor or pharmacist whether your medication includes any of these ingredients. This will reduce the risk of bruising or bleeding at the point of injection.

Because bruising and swelling are the most common side effects, especially in the lower face, schedule appointments at least 48 hours before any major event. Please let us know if you have been to the dentist / oral hygienist or if you are planning to go to the dentist/ hygienist in the next 4 weeks.

Why? When your teeth are cleaned, bacteria are released into your mouth and travel into the bloodstream. CaHA injectables of any kind are considered an implant, a foreign substance in the body, and these excess bacteria increase the risk of infection and the formation of Biofilm (bacterial infection). If this is your first visit you will need to provide us with information regarding your medical history and any medical concerns, as well as details of any allergies you have or medications you are taking.

Please contact us to find out our specific requirements before undergoing a Dual Effect Hybrid Facial Filler procedure at Dr Nerina Wilkinson + Associates. 

Day of Hybrid Filler procedure

Please note that you will have to arrive without make-up to prevent any Biofilm (bacterial infections) when doing Hybrid Facial Filler treatments.

Once the Doctor has determined and confirmed your areas of concern by means of detailed consultation, they will proceed. It’s important that you’re honest with the doctor about your medical history, medication, and expectations during this time. So that, if they’re not in line with the treatment, then another can be recommended instead.

After Hybrid Filler procedures

For 2 hours: Avoid make-up at the injection site to avoid contamination in the area.

For 4 hours: Do not lie down or do strenuous exercise and similar activities, nor should you do anything that increases the blood flow to the injected area

For 12 hours: Massage the treated areas if you feel any small bumps

For 24 hours: Avoid any high-intensity exercise or activities, exposure to sunlight, tanning beds, or extreme weather conditions

For 24 hours: Apply an ice pack or cold compressions to the treated areas as with most injectable treatments there may be some redness, swelling, and irritation.

For 1 month: Avoid dental procedures and any invasive skin treatments

For 3 months: Avoid any other injectable treatments, such as dermal fillers.

Please follow these instructions carefully to aid in achieving optimal results: Please note that no treatment can halt the ageing process completely, you will require top-up treatments if you want to maintain the effect, so please ask your doctor when she would recommend rescheduling another appointment.

Dual Effect Hybrid Facial Fillers Before & After Photos

hybrid facial filler before and after photo 3

What are the possible risks and complications associated with hybrid facial fillers?

Hybrid fillers Side Effects, Risks & Complications

As with other injectable treatments, the most common side effects after injection with hybrid fillers include:

  • Redness
  • Swelling
  • Pain
  • Tenderness and itching
  • These are often mild and typically get better within 24-48 hours, while swelling may take up to a week to completely go away.

Applying ice packs or cold compresses to the treated areas for 24 hours after treatment can help to reduce redness, swelling, and irritation. it is also possible that you may feel small bumps under the skin in the injected areas. If this happens, make sure to massage the skin in these areas. There are other, less common side effects with hybrid fillers, which your treating doctor will be able to discuss with you during your consultation.

Remember: It can only be injected in the lower face and should only be injected by an experienced aesthetic doctor.

Contraindications associated with Dual Effect Hybrid Fillers

  • Allergy/hypersensitivity to fillers or lidocaine
  • An open wound with infection localized/systemic infection (bacterial or viral) A low platelet count
  • Pregnancy and/or nursing mothers
  • Auto-immune disease Diabetes
  • Poor wound healing or Keloidosis
  • Patients on anti-coagulants
  • Active skin cancer

Are there alternative procedures to hybrid fillers?

Yes, there are alternative treatments for reducing issues associated with facial skin ageing and improving skin architecture.

Natural Lift procedures restore youth and refine the facial profile allowing light to naturally reflect from the skin, and involves the precise placement of very small volumes of hyaluronic acid filler in multiple areas of the face to build deep structural support and the shift the balance between the elevator and depressor muscles of the face.

Bio skin remodelling involves the use of stabilised Hyaluronic Acid boosters to provide noticeable improvements in the hydration, tightness and firmness of your skin.

Botulinum toxin treatments are popular non-surgical procedures that appeal to adults looking to attain a more youthful and relaxed appearance, and also to younger clients who want to prevent the formation of fine lines and wrinkles.

How do hybrid fillers differ from bio-remodellers or dermal fillers?

Bio-remodellers and Hyaluronic Acid facial fillers work differently and may not give the same results. Hybrid fillers combine Calcium Hydroxyapatite with Hyaluronic Acid, capturing the potential benefits of both in one treatment. Hybrid fillers may offer the combined action of hyaluronic acid lift and lasting collagen production from Calcium Hydroxyapatite in one injection. Hybrid Filler treatments result in an immediate improvement and are followed by sustained tightening for up to 3 years due to the presence of CaHA which stimulates the formation of new collagen.

What type of anesthesia is used when performing hybrid facial filler procedures?

Hybrid facial fillers contain 0.3% lidocaine hydrochloride, an anaesthetic, to reduce pain during treatment. It is as comfortable as other fillers.

Are hybrid facial filler treatments painful?

Hybrid facial fillers contain 0.3% lidocaine hydrochloride, an anaesthetic, to reduce pain during treatment. It is as comfortable as other fillers.

Where is a hybrid fillers performed in Cape Town?

Dr Nerina Wilkinson + Associates is a private, high-end, luxurious clinic located in the prestigious V&A Waterfront in Cape Town. Dr Wilkinson founded the House of Aesthetic Couture and Skin Science. Your treatment will be performed at this clinic.


Similar to Hybrid Facial Fillers


Natural-Lift combines sophisticated techniques to microscuplt the proportions of the face to restore youth and refine the facial profile, allowing light to naturally reflect from the skin.
View Treatment

Bio skin remodelling

Bio skin remodelling involves the use of stabilised hyaluronic acid boosters to provide noticeable improvements in the hydration, tightness and firmness of your skin.
View Treatment

Botulinum Toxin Treatments

Popular non-surgical procedures that appeal to adults looking to attain a more youthful and relaxed appearance, and also to younger clients who want to prevent the formation of fine lines and wrinkles.
View Treatment


The Aesthetic Couture Team

Dr Narina Wilkinson and team

About Dr Nerina Wilkinson + Associates

We pride ourselves on affording our patients the best service through their journey with us. Whether you are having a skin treatment with one of our skin care experts, aesthetic medical treatments or having cosmetic surgery, the team at Dr Nerina Wilkinson and Associates will be there for you, every step of the way.

Skin Science & Aesthetic Couture

Our team has pioneered highly effective, science-driven techniques. Integrating the most cutting-edge technologies, state-of-the-art equipment and sound scientific research. We design game-changing protocols that redefine skin care, aesthetic medicine, and plastic surgery.

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Our Patients'


An excellent team who will tailor make a skin treatment plan for you. They are all extremely knowledgeable and professional and use all the latest anti aging technologies and treatments. Amazing attention to detail from the beautiful space to the follow up care kits and check in emails from the therapists. Really a five star experience.

J Anastasopoulos

I have been with Dr Nerina Wilkinson and her team since 2021 and the level of professionalism is unmatched. So are the treatments, they truly have a solution for almost every skin or aesthetic concern. Could not love them more!

A Davids

My experience at Dr Nerina Wilkinson has been nothing but significant! I feel that for the first time, I understand my skin. Thanks to the lovely Louné, that has created a specific skin plan and routine for me. I am 39 years old and struggle with Pigmentation and Skin ageing. Our goal is to make my skin look as fresh, natural and glowing as possible. I have the utmost confidence in Louné to reach my goal. I started my journey with them in January 2023 and my results after doing a Meline Peel are already proofs that I am on the best plan. I am excited and confident to reach my goal and cannot wait for my next appointment! I would definitely recommend their professional opinions.

T Strauss

This is my honest review. I was very sceptical when I made an appointment at Dr Nerina Wilkinson and Associates, I thought like every other place that has influencers going there that it wouldn’t hold up to its reputation. I was wrong! Very wrong. Dr Cindy Kerbel was incredible, she took her time to explain not only my skin but all the available options for my skin. She has such a warm and kind energy. You immediately feel cared for. Honestly you won’t regret going here. I cannot wait for my next appointment. Thank you!

J Bentel

To avoid prolixity, you know your people are undeniably unbeatable when arguments relating to your age arise in conversations (read online dating apps). Despite clinging to the ‘wrong side’ of 30, I’ve made peace with those who assume I am still at varsity. Between Marisa and Bernice (with a shout-out to Natalie (as well as the rest of the team)) my skin and jawline (and the rest) have never looked more delicious. And when the Finance and Facility Manager is also a vibe, you know you’ve found a gem of a team! In short, I’m addicted (hypothetically, of course) to the needles (in a healthy wholesome way, naturally) and am never looking back (in particular at old Facebook photos when youth was allegedly in my favour). Thanks for keeping my aesthetic *ish together.

A Wright

I am so glad that, at the age of 30, I finally decided to come here! Such a warm and professional atmosphere, and Chantel made me feel so comfortable and excited for this journey. After my in-depth skin analysis and consultation, I was very happy with the first treatment, and for what has been planned ahead. Thank you!

F Badenhorst

I’ve gone for 2 appointments so far and 1. the service is incredible, such friendly and professional staff, 2. I had my skin analysed and then also went for a skin treatment and my skin is thanking me for it. I cannot wait to go back for more treatments. Highly recommend.

N Jacobs

I recently went to Dr Nerina Wilkinson + Associates to help me with my Rosacea. Walking into their beautiful, tranquil space is transforming alone. I love that they have a signature scent, which smells amazing. Each member of the team is passionate about what they do and incredibly knowledgeable, whilst always staying informed with the latest in skincare, technology etc.

B Georgiades

During my extended stay in Cape Town, I (Black American female), visited Dr. Nerina Wilkinson + Associates to maintain my skincare regimen while abroad. I was fortunate to work with my skincare specialist to develop a tailored skincare treatment. Not only did I receive great service, but she also provided detailed insight into the current state of my skin and offered additional recommendations for overall skin health. Chantel was excellent, demonstrating both kindness and informative expertise, and the facility was beautiful. And overall, I did see improvement in my skin’s texture and evenness, but I still have a ways to go.

C Okpara

Growing up I did not pay much attention to looking after my skin properly, but after starting my journey with Dr Nerina Wilkinson + Associates it has become one of the most important steps in my daily routine and I am loving it thanks to their delightful, informed and supportive team. I have always struggled with broken capillaries and dehydration, but have never known how to go about treating it and preventing further damage in the future. I had my first IPL session last week and I am absolutely shocked by the amazing results thus far. I was very wary about leaving my home during the COVID19 pandemic, but the team at Dr Nerina Wilkinson + Associates not only made me feel incredibly safe but I was also treated like a true queen during my session. After the treatment I received a ‘lucky packet’ of aftercare products and Bernice was there at my every beck and call (as I had many questions which were answered in such a timely and gracious manner). She also recommended products that have made my face feel softer and more youthful than ever before and I can already start seeing/feeling a difference. I am so grateful to the incredible team and I look forward to a future of beautiful care and loving myself in my own skin.

K Fourie

Growing up in the US, I went to dermatologist after dermatologist, and each one said the same three things: I have acne, it’s genetic, and it could be a lot worse. When I moved to Cape Town a few years ago, I heard from a friend that I needed to go see the women at the Nerina Wilkinson skin clinic, so I made an appointment – but I didn’t expect anything different. I left their office after my first appointment with Kim and I had some real hope for my skin to improve. She changed my home care, worked out a long term plan for me, and even gave me her personal cell number so I could message her if things weren’t working. It’s been over two years now and I have never been so happy with my skin. Kim and the other women at the skin clinic form the kindest and most caring team of professionals and I can’t thank them enough. From scalp PRP treatments for thinning hair, to lasers and peels for my rosacea, I’ve tried my fair share of treatments at this office and every single one of them has been worth it – I can honestly say these women have helped me feel like the best version of myself!

A Newell

“I have spent too much money over the past 10 years in hope to sort out my pigmentation and skin texture. Visited many (un)professionals and bought the most mediocre skincare. I heard about Dr Nerina via a friend. My last hope and the best decision I made. I was introduced to the Me Line peel and their skincare…this is now my go to as my skin has never looked this good and healthy ever. Extremely professional team, Bianca was my therapist. If you are looking for skin changing results and are serious about proper skincare, you should visit them. It’s worth all the money you will spend. An investment worth it…”


“Thank you to the wonderful ladies at your skin clinic. I have always suffered from problem skin. They have over the last few months advised me on the correct skincare and through their dedicated treatments I am now proud to show my skin without wearing too much makeup.”

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“Every day I look in the mirror, I can’t believe that this new skin in mine! I reached a point in my life where I thought that I would have to live with the consequences of the severe sun damage I have caused myself through years of surfing. Not only have you given me new skin Nerina, you have actually given me a new life.”

L.S, CO2 Laser Resurfacing Treatment

“My grateful thanks to you all for everything you do for me, and I mean that from the heart of my bottom!”

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