Cosmelan and Dermamelan is a clinical topical treatment specifically formulated to not only depigment the skin at surface level but also treat underlying causes.

Depigmentation (Cosmelan/Dermamelan) Treatment in South Africa

At Dr. Nerina Wilkinson + Associates, we harness breakthrough treatments for depigmentation.

The tailored Cosmelan/Dermamelan treatment aims to provide an even skin tone and a revitalised, radiant appearance.

What is Cosmelan/Dermamelan by Mesoestetic?

Cosmelan and Dermamelan by Mesoestetic is a clinical topical treatment specifically formulated to not only depigment the skin at the surface level but also treat underlying causes. This effectively removes and brightens dark patches, resulting in a brighter, smoother and more even complexion.

Cosmelan and Dermamelan are considered the gold standard treatment for the treatments of melasma and other pigmentation conditions worldwide.

Learn about our approach, how Cosmelan/Dermamelan treatments work and contact us to book a consultation.

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Frequently asked questions about ageing depigmentation (cosmelan/dermamelan) treatments

Our approach to a Cosmelan/Dermamelan treatment

At Dr. Nerina Wilkinson + Associates, we are devoted to offering a personalised approach to your skin’s unique needs.

Prior to initiating any treatments, our patients undergo a thorough examination, inclusive of a cutting-edge VISIA Skin Analysis. This essential step ensures we devise a treatment plan that’s not only tailored to individual needs but also guarantees tangible results over time.

With Dr. Nerina Wilkinson’s unwavering commitment to excellence, our esteemed team continuously sets the bar higher, employing only the most advanced medical tools and products. We prioritise creating a sanctuary of luxury and safety, ensuring all your skincare needs are met with unparalleled expertise.

Every Cosmelan/Dermamelan treatment we provide is intricately tailored to target individual concerns and aesthetic aspirations.

What is depigmentation?

Depigmentation is a specialised treatment focused on reducing skin pigmentation by targeting the production of melanin. The primary cause of skin pigmentation is an overproduction of melanin, which leads to the formation of dark patches on the skin. Depigmentation treatments effectively work to lighten these dark patches, restoring a more even and radiant complexion.

At Dr. Nerina Wilkinson + Associates, we employ state-of-the-art depigmentation treatments to offer solutions tailored to your skin’s specific needs. By intervening in the melanin production process, these treatments not only lighten existing dark patches but also prevent the formation of new ones. With a comprehensive understanding of the complexities of skin pigmentation, our team ensures that each treatment is carefully curated to produce the most effective and lasting results.

Who is the ideal candidate for Cosmelan/Dermamelan treatments?

Cosmelan/Dermamelan treatments are designed for individuals experiencing uneven skin pigmentation, whether from sun damage, hormonal changes, or other factors. If dark patches, discolouration, or melasma are a concern for you, this might be an ideal solution.

Always start with a professional consultation with qualified and experienced specialists for an in-depth analysis of your pigmentation and to reach a good understanding of your skincare concerns and goals.

Schedule a personalised skincare consultation to discuss your concerns and goals with a specialist from our team.

How does a Cosmelan and Dermamelan treatment work?

The Cosmelan and Dermamelan treatment begins with an in-clinic depigmenting mask application, followed by an intensive home care regime involving the application of depigmenting creams at home for at least 6 – 9 months following the in-clinic treatment.

We usually recommend coming in for your treatment first thing in the morning.
Part one of your treatment will be performed in the Skin Clinic. The skin will be cleansed and wiped with a degreasing solution. The brown Cosmelan or Dermamelan mask will be applied to the skin in a thick layer.

You will then go home with the mask which needs to stay on for the next 8 to 10 hours.

You will then wash the mask off at home and apply a specific aftercare creams that form part of the Cosmelan/Dermamelan maintenance regime.

Once instructed you begin with part two, the Cosmelan or Dermamelan maintenance cream, you will be advised on the frequency and guided as you start seeing results.

What type of pigmentation can be treated with Cosmelan and Dermamelan treatments?

The most common type of pigmentation treated with Cosmelan and Dermamelan is melasma. Melasma is usually triggered by hormonal changes within the body and will show up as an even pattern often covering the cheeks, temples, forehead and top lip. Sunspots can also be treated effectively as well as post-inflammatory hyperpigmentation, usually seen after acne breakouts.

What areas can be treated with Cosmelan/Dermamelan treatments?

Cosmelan/Dermamelan treatments are medical depigmenting methods designed to take corrective action against dark spots and skin pigmentation issues. Whether you’re aiming to alleviate sun damage or other skin discolourations, or struggle with melasma, Cosmelan/Dermamelan offers an effective solution to bring back the skin’s natural radiance and glow.

What are the benefits of Cosmelan/Dermamelan treatments?

Cosmelan/Dermamelan treatments stand out for their intensive depigmenting action, ensuring a clearer and more harmonised complexion. After undergoing the treatment, patients often witness remarkable improvements in the overall tone and vibrancy of their skin.

The benefits of Cosmelan/Dermamelan include:

  • Effectively removes dark spots and reduces skin pigmentation issues.
  • Intensive depigmenting action that targets even deep-set discolorations.
  • Evens out the skin tone, offering a brighter and rejuvenated appearance.
  • Addresses sun damage and other external factors leading to skin darkening.
  • Boosts the skin’s natural radiance by eliminating imperfections.

How long does it take to see results from Cosmelan/Dermamelan treatments?

Dark spots and pigmentation irregularities typically start to fade within the first week following the treatment. The full benefits of the Cosmelan/Dermamelan treatments, with a more even and brightened skin tone, become increasingly evident over the subsequent 4 to 6 weeks. Continued improvements can be observed for several months as the skin undergoes its natural regeneration process.

How many Cosmelan/Dermamelan treatments do you need to see results?

For dark spots and superficial pigmentation, most individuals observe noticeable improvement after just one Cosmelan/Dermamelan treatment. However, for deeper pigmentation or more extensive skin discolouration, 2 – 3 treatments might be necessary for optimal results. It is important to note that Cosmelan/Dermamelan in-clinic treatments must be followed by the specific maintenance at-home protocol in order to support and maintain results.

How often should I have a Cosmelan or Dermamelan treatment?

The application is usually a once-off treatment but may be repeated 4 – 6 weeks later if necessary. It is vital to continue with the recommended homecare for at least 6 months following the treatment; this is known as the stabilisation phase.

Some forms of pigmentation will need to be followed by Cosmelan or Dermamelan homecare indefinitely to prevent pigmentation from resurfacing; your Skincare Specialist will guide you through the entire process.

How long does it take to perform a Cosmelan/Dermamelan treatment?

The duration of a Cosmelan/Dermamelan treatment can vary based on the extent of the area being addressed, but typically, the procedure ranges from 30 minutes to 90 minutes. This includes the application of the depigmenting mask and any necessary preparatory steps.

What is the recovery time for a Cosmelan or Dermamelan depigmentation treatment?

Usually, the skin appears red and feels sunburnt for the first 2 – 3 days.
Flaking and peeling usually begins around day 3 and can proceed for up to one week post-treatment.

Once flaking subsides you will already start to notice improvement of the pigmentation. For further improvement and maintenance, you will begin with the home treatment after Cosmelan or Dermamelan. Initially, when using your maintenance creams, the skin will feel sensitive, tight and may flake further, this usually subsides after about 2 weeks.

How much does a Cosmelan/Dermamelan treatment cost?

The cost of a Cosmelan/Dermamelan treatment will vary depending on the extent of pigmentation and the specific needs of the patient. This will be determined during your initial consultation with our specialist.

The average cost for a standard Cosmelan/Dermamelan treatment is +/- R 15 000 – R 23 000. For those with deeper pigmentation or requiring additional sessions, costs may vary.

Additional costs you might encounter include:

Consultation fee of R500
Post-treatment skincare products +/- R 800 – R 1 200

(Please note that these fees are merely estimative and may be subject to change after your consultation with our specialist.)

Are there alternative treatments for Cosmelan/Dermamelan treatments?

There are several other treatments that can address skin pigmentation and enhance overall complexion, and include (but are not limited to) some of the treatments below:

  • Lumecca IPL: This Intense Pulsed Light therapy can target pigmented lesions and improve the appearance of sun damage, giving the skin a rejuvenated appearance.
  • 3D Medical Skin Needling: A cutting-edge treatment that stimulates the skin’s natural healing response, promoting collagen production and reducing the appearance of pigmentation.
  • Glow Getter: An innovative treatment designed to impart a radiant complexion by targeting skin unevenness and discolouration.
  • I-Peel-L Bespoke: An amalgamation of advanced therapies, I-Peel-L Bespoke combines the power of Intense Pulsed Light with chemical peels to holistically address concerns such as sun damage, wrinkles, and pigmentation.

For a more tailored solution to your specific needs, it’s advisable to schedule a consultation with our specialists. They can provide a comprehensive evaluation of your skin’s requirements and design a bespoke treatment plan to achieve your desired outcomes.

Are Cosmelan/Dermamelan treatments safe?

Yes, when administered by a qualified Skincare Specialist in a sterile medical setting, Cosmelan/Dermamelan treatments are considered safe. They are designed to cater to various skin types, ensuring effective results across different types of skin. Proper assessment and guidance further ensure the treatment’s suitability for the patient’s specific needs.

What are the possible risks, side effects and complications associated with Cosmelan/Dermamelan treatments?

When a Cosmelan/Dermamelan treatment is administered by a qualified Skincare Specialist in a sterile medical environment, the associated risks are notably minimised.

Cosmelan/Dermamelan treatments, like any other advanced skin treatment, can lead to certain reactions in sensitive individuals. Some may experience mild erythema or redness, which usually subsides within a few hours. On occasion, individuals might notice transient hypo- or hyperpigmentation, indicating temporary lightening or darkening of the skin. There have been rare instances where patients report minor skin irritation, which generally resolves swiftly with appropriate aftercare.

While the vast majority of patients don’t experience these side effects, it remains essential to be informed about these possibilities. It’s always advised to have a detailed discussion with your Skincare Specialist to understand the treatment comprehensively and ensure you’re making the best choice for your skin’s well-being.

Cosmelan/Dermamelan treatments: Before and After

Every client’s skincare journey with us is crafted with precision and individual attention. Our approach initiates with a comprehensive VISIA Skin Care Analysis that provides an objective assessment of your skin’s condition. This is complemented by an in-depth consultation with our Skincare Specialist to understand and address your unique skin concerns.

What to do before the Cosmelan/Dermamelan treatments

  • Refrain from using aggressive at-home facial treatments or exfoliating procedures for a week leading up to your session.
  • Limit direct sun exposure and abstain from tanning sessions for at least a week before your treatment.
  • Familiarise yourself with the skincare products you regularly use, and consider bringing a list with you. This assists your Skincare Specialist in recommending the most appropriate products tailored to your needs.
  • Ensure you inform your Skincare Specialist about any medications, past skin conditions, and current health conditions. It’s imperative to understand how over-the-counter or prescribed medications might interact with the treatment.
  • If you’re preparing your skin for a significant event and haven’t previously undergone skincare treatments, consider booking your session at least six weeks ahead. Scheduling a follow-up closer to the event date ensures your skin appears its best and any unforeseen reactions are managed promptly.
  • Openly discuss your skin goals and concerns. Our Skincare Specialists are trained professionals, adept at creating a comprehensive plan designed around your specific objectives.
  • It’s recommended to avoid any aesthetic procedures (like Botulinum Toxin, Facial Fillers, or Threads) for 2 weeks before and after the Cosmelan/Dermamelan treatment.

Day of Cosmelan/Dermamelan treatments

On your first visit to our Skin Clinic, a concise medical questionnaire awaits your completion. This ensures your Skincare Specialist possesses the essential information to select the optimal treatment protocol tailored for you. For the treatment, access to your face, neck, and possibly shoulders will be necessary, so be prepared to change into a provided robe. Your treatment process will entail:

  • A thorough skin cleansing
  • Application of the Cosmelan/Dermamelan treatment mask
  • A resting phase, allowing the mask to penetrate and work on the skin
  • Gentle removal of the mask followed by a soothing serum or moisturiser.

After Cosmelan/Dermamelan treatments

Post-treatment, it’s not uncommon to notice some skin redness, akin to mild sunburn, and slight skin tightness. The treated area might undergo a peeling phase as the skin rejuvenates and the pigmented lesions lighten. Proper moisturisation and adherence to the provided aftercare routine will assist in speeding up the recovery. On average, complete recovery and visible results are usually noticeable within a week, with optimal results becoming evident over subsequent weeks as the skin continues its renewal process.


  • Begin and end your day by cleansing your skin using an antibacterial wash with lukewarm to cool water.
  • Cooling gels recommended for post-treatment applications can be applied to soothe any irritation. Your Skincare Specialist will offer guidance on the best product choices tailored for your skin’s needs.
  • Regularly moisturise with a product advised by your Skincare Specialist, ensuring it supports the healing process and enhances the treatment outcomes.
  • Ensure you apply an SPF 50 daily, as your skin will be more sensitive to UV exposure.
  • Please refrain from facial waxing for at least 7 days after the treatment.
  • Limit direct sun exposure for the initial 2 – 7 days post-treatment, to allow your skin ample recovery time.
  • Strenuous exercises or activities that induce excessive sweating should be avoided for the first 24 hours after the treatment.

Where are Cosmelan/Dermamelan treatments performed in Cape Town?

Dr. Nerina Wilkinson + Associates offers the renowned Cosmelan/Dermamelan treatments in their state-of-the-art facility. Located in the esteemed V&A Waterfront in Cape Town, this private and opulent clinic epitomises excellence in aesthetic treatments. Trust in Dr. Wilkinson’s House of Aesthetic Couture and Skin Science for your Cosmelan/Dermamelan treatments, all carried out within the sophisticated confines of Dr. Wilkinson’s clinic.


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The Skin Science Team

About Dr Nerina Wilkinson + Associates

We pride ourselves on affording our patients the best service through their journey with us. Whether you are having a skin treatment with one of our skincare experts, aesthetic medical treatments or cosmetic surgery, the team at Dr Nerina Wilkinson and Associates will be there for you, every step of the way.

Skin Science & Aesthetic Couture

As an all-female team, we understand the importance of naturally beautiful looking skin. Known as leaders in the skincare industry, we have pioneered industry-changing rejuvenation techniques and signature procedures such as 3D Microneedling™, Forma Hydralyft™, and Glow Getter™.

Our Patients'


An excellent team who will tailor make a skin treatment plan for you. They are all extremely knowledgeable and professional and use all the latest anti aging technologies and treatments. Amazing attention to detail from the beautiful space to the follow up care kits and check in emails from the therapists. Really a five star experience.

J Anastasopoulos

I have been with Dr Nerina Wilkinson and her team since 2021 and the level of professionalism is unmatched. So are the treatments, they truly have a solution for almost every skin or aesthetic concern. Could not love them more!

A Davids

My experience at Dr Nerina Wilkinson has been nothing but significant! I feel that for the first time, I understand my skin. Thanks to the lovely Louné, that has created a specific skin plan and routine for me. I am 39 years old and struggle with Pigmentation and Skin ageing. Our goal is to make my skin look as fresh, natural and glowing as possible. I have the utmost confidence in Louné to reach my goal. I started my journey with them in January 2023 and my results after doing a Meline Peel are already proofs that I am on the best plan. I am excited and confident to reach my goal and cannot wait for my next appointment! I would definitely recommend their professional opinions.

T Strauss

This is my honest review. I was very sceptical when I made an appointment at Dr Nerina Wilkinson and Associates, I thought like every other place that has influencers going there that it wouldn’t hold up to its reputation. I was wrong! Very wrong. Dr Cindy Kerbel was incredible, she took her time to explain not only my skin but all the available options for my skin. She has such a warm and kind energy. You immediately feel cared for. Honestly you won’t regret going here. I cannot wait for my next appointment. Thank you!

J Bentel

To avoid prolixity, you know your people are undeniably unbeatable when arguments relating to your age arise in conversations (read online dating apps). Despite clinging to the ‘wrong side’ of 30, I’ve made peace with those who assume I am still at varsity. Between Marisa and Bernice (with a shout-out to Natalie (as well as the rest of the team)) my skin and jawline (and the rest) have never looked more delicious. And when the Finance and Facility Manager is also a vibe, you know you’ve found a gem of a team! In short, I’m addicted (hypothetically, of course) to the needles (in a healthy wholesome way, naturally) and am never looking back (in particular at old Facebook photos when youth was allegedly in my favour). Thanks for keeping my aesthetic *ish together.

A Wright

I am so glad that, at the age of 30, I finally decided to come here! Such a warm and professional atmosphere, and Chantel made me feel so comfortable and excited for this journey. After my in-depth skin analysis and consultation, I was very happy with the first treatment, and for what has been planned ahead. Thank you!

F Badenhorst

I’ve gone for 2 appointments so far and 1. the service is incredible, such friendly and professional staff, 2. I had my skin analysed and then also went for a skin treatment and my skin is thanking me for it. I cannot wait to go back for more treatments. Highly recommend.

N Jacobs

I recently went to Dr Nerina Wilkinson + Associates to help me with my Rosacea. Walking into their beautiful, tranquil space is transforming alone. I love that they have a signature scent, which smells amazing. Each member of the team is passionate about what they do and incredibly knowledgeable, whilst always staying informed with the latest in skincare, technology etc.

B Georgiades

During my extended stay in Cape Town, I (Black American female), visited Dr. Nerina Wilkinson + Associates to maintain my skincare regimen while abroad. I was fortunate to work with my skincare specialist to develop a tailored skincare treatment. Not only did I receive great service, but she also provided detailed insight into the current state of my skin and offered additional recommendations for overall skin health. Chantel was excellent, demonstrating both kindness and informative expertise, and the facility was beautiful. And overall, I did see improvement in my skin’s texture and evenness, but I still have a ways to go.

C Okpara

Growing up I did not pay much attention to looking after my skin properly, but after starting my journey with Dr Nerina Wilkinson + Associates it has become one of the most important steps in my daily routine and I am loving it thanks to their delightful, informed and supportive team. I have always struggled with broken capillaries and dehydration, but have never known how to go about treating it and preventing further damage in the future. I had my first IPL session last week and I am absolutely shocked by the amazing results thus far. I was very wary about leaving my home during the COVID19 pandemic, but the team at Dr Nerina Wilkinson + Associates not only made me feel incredibly safe but I was also treated like a true queen during my session. After the treatment I received a ‘lucky packet’ of aftercare products and Bernice was there at my every beck and call (as I had many questions which were answered in such a timely and gracious manner). She also recommended products that have made my face feel softer and more youthful than ever before and I can already start seeing/feeling a difference. I am so grateful to the incredible team and I look forward to a future of beautiful care and loving myself in my own skin.

K Fourie

Growing up in the US, I went to dermatologist after dermatologist, and each one said the same three things: I have acne, it’s genetic, and it could be a lot worse. When I moved to Cape Town a few years ago, I heard from a friend that I needed to go see the women at the Nerina Wilkinson skin clinic, so I made an appointment – but I didn’t expect anything different. I left their office after my first appointment with Kim and I had some real hope for my skin to improve. She changed my home care, worked out a long term plan for me, and even gave me her personal cell number so I could message her if things weren’t working. It’s been over two years now and I have never been so happy with my skin. Kim and the other women at the skin clinic form the kindest and most caring team of professionals and I can’t thank them enough. From scalp PRP treatments for thinning hair, to lasers and peels for my rosacea, I’ve tried my fair share of treatments at this office and every single one of them has been worth it – I can honestly say these women have helped me feel like the best version of myself!

A Newell

“I have spent too much money over the past 10 years in hope to sort out my pigmentation and skin texture. Visited many (un)professionals and bought the most mediocre skincare. I heard about Dr Nerina via a friend. My last hope and the best decision I made. I was introduced to the Me Line peel and their skincare…this is now my go to as my skin has never looked this good and healthy ever. Extremely professional team, Bianca was my therapist. If you are looking for skin changing results and are serious about proper skincare, you should visit them. It’s worth all the money you will spend. An investment worth it…”


“Thank you to the wonderful ladies at your skin clinic. I have always suffered from problem skin. They have over the last few months advised me on the correct skincare and through their dedicated treatments I am now proud to show my skin without wearing too much makeup.”

Skincare Treatments

“Every day I look in the mirror, I can’t believe that this new skin in mine! I reached a point in my life where I thought that I would have to live with the consequences of the severe sun damage I have caused myself through years of surfing. Not only have you given me new skin Nerina, you have actually given me a new life.”

L.S, CO2 Laser Resurfacing Treatment

“My grateful thanks to you all for everything you do for me, and I mean that from the heart of my bottom!”

Skin Science Treatments

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Depigmentation (cosmelan/dermamelan) treatment journey

At our premier skin clinic and plastic surgery practice nestled in the V&A Waterfront, Cape Town, our devoted team of skincare specialists stand ready to accompany you through each phase of your depigmentation journey.

With unmatched experience and passion, we promise tailored Cosmelan/Dermamelan treatments to help you unveil a rejuvenated and radiant complexion. Contact us today and take the first step in your depigmentation treatment journey.